Scientific Publications & Patents:
1. Dmitriy Ovcharenko, Friedrich Stölzel, David Poitz, Fernando Fierro, Markus Schaich, Andreas Neubauer, Kevin Kelnar, Timothy Davison, Carsten Müller-Tidow, Christian Thiede, Martin Bornhäuser, Gerhard Ehninger, David Brown, Thomas Illmer. miR-10a overexpression is associated with NPM1 mutations and Mdm4 downregulation in intermediate-risk acute myeloid leukemia. Experimental Hematology (in press).
2. Teichler S, Illmer T, Roemhild J, Ovcharenko D, Stiewe T, Neubauer A. MicroRNA29a regulates the expression of the nuclear oncogene Ski. Blood (2011). Full Text
3. Sirotkin AV, Laukova M, Ovcharenko D, Brenaut P, Mlyncek M. Identification of microRNAs controlling human ovarian cell proliferation and apoptosis. Journal of Cellular Physiology 223:49-56 (2010). Full Text
4. Sirotkin AV, Ovcharenko D, Mlyncek M. Identification of protein kinases that control ovarian hormone release by selective siRNAs. Journal of Molecular Endocrinology 44:45-53 (2010). Full Text
5. Dmitriy Ovcharenko, Kevin Kelnar, Charles Johnson, Nan Leng, and David Brown. Genome-scale microRNA and small interfering RNA (siRNA) screens identify small RNA modulators of TRAIL-induced apoptosis pathway. Cancer Research 67: p.10782-10788 (2007). Full Text
6. Charles D. Johnson, Aurora Esquela-Kerscher, Giovanni Stefani, Mike Byrom, Kevin Kelnar, Dmitriy Ovcharenko, Mike Wilson, Xiaowei Wang, Jeffrey Shelton, Jaclyn Shingara, Lena Chin, David Brown, and Frank J. Slack. The let-7 microRNA represses cell proliferation pathways in human cells. Cancer Research 67: p.7713-7722 (2007). Full Text
7. Dmitriy Ovcharenko et al. High-throughput RNAi screening in vitro: From cell lines to primary cells. RNA 11: p.985-993 (2005). Full Text
8. Dmitriy Ovcharenko et al. Mir-10a overexpression is linked to a HOX gene cluster in intermediate risk acute myeloid leukemia (AML) patients with NPM1 mutations. (in prep)
9. Sachse et al. High throughput RNAi strategies for target discovery and validation by using synthetic siRNAs: functional genomics investigations of biological pathways. Methods in Enzymology 392:p.242-277 (2005). PDF
10. Tong et al. Neutrophil gelatinase associated lipocalin as a survival factor. Biochemical Journal 391: p.441-448 (2005). Full Text
11. Sirotkin et al. Protein kinases controlling PCNA and p53 expression in human ovarian cells. Funct Integr Genomics 9:185-95 (2009). Full Text
12. Loots et al. Genomic deletion of a long-range bone enhancer misregulates sclerostin in Van Buchem disease. Genome Research 15:p.928-935 (2005). Full Text
13. Sirotkin et al. Identification of microRNAs controlling human ovarian cell steroidogenesis via a genome-scale screen. Journal of Cellular Physiology 219:415-20 (2009).
14. Boffelli et al. Phylogenetic Shadowing of Primate Sequences to Find Functional Regions of the Human Genome. Science 299:p.1391-1394 (2003). Full Text
15. Baoum A et al. Calcium condensed cell penetrating peptide complexes offer highly efficient, low toxicity gene silencing. (in prep)
16. Patent: Methods and compositions involving miRNA and miRNA inhibitor molecules. USA patent number #7,960,359. Issue date: June 14, 2011.
17. Patent: System and method for electroporating a sample. USA patent number #7,393,681. Issue date: July 1, 2008.
18. Patent: System and method for electroporating a sample. USA patent number #6,897,069. Issue date: May 24, 2005.
19. Patent application #20090192114: miR-10 Regulated Genes and Pathways as Targets for Therapeutic Intervention.
20. Patent application #20090176723: Methods and compositions involving miRNA and miRNA inhibitor molecules.
21. Patent application #20090092974: MicroRNAs differentially expressed in leukemia and uses thereof.
22. Dmitriy Ovcharenko, Thomas Illmer, Jeffrey Shelton, Emmanuel Labourier, David Brown. Expression profiling and functional studies reveal a potential role for microRNAs in human acute myeloid leukemia. The American Society of Cell Biology, San Francisco, CA (2005).
23. Dmitriy Ovcharenko, Kevin Kelnar, Angie Cheng, David Wang, Lance Ford. The use of miRNA and siRNA libraries to identify genes involved in the regulation of hTERT transcription. The American Society of Cell Biology, San Francisco, CA (2005).
24. Richard Jarvis, Mike Byrom, Dmitriy Ovcharenko, Christina Buchanan, David Brown. SiRNA libraries as tools for target identification. The American Society of Cell Biology, San Francisco, CA (2005).
25. Dmitriy Ovcharenko. High throughput in vitro RNAi screening: From cell lines to primary cells. Experimental Biology (FASEB),San Diego, CA (2005).
26. Dmitriy Ovcharenko. High throughput in vitro RNAi screening: From cell lines to primary cells. AACR 96th Annual Meeting, RNA Interference, Small Interfering RNAs, and MicroRNAs: From Mechanism to Cancer Therapeutics, Anaheim, CA (2005).
27. Dmitriy Ovcharenko, Richard Jarvis. High Throughput In Vitro RNAi Screening: From Cell Lines To Primary Cells. Twelfth International Symposium on Recent Advances in Drug Delivery Systems (2005).
28. Dmitriy Ovcharenko, Kevin Kelnar, Richard Jarvis. Efficient Delivery of siRNA to Primary Cells and Hard-to-Transfect Cell lines. Gene Delivery 3rd Annual International Conference (2003).
29. Dmitriy Ovcharenko. High throughput in vitro RNAi screening: From cell lines to primary cells. AACR 96th Annual Meeting, Cellular and Molecular Biology Symposium, Anaheim, CA (2005).
30. Dmitriy Ovcharenko, Richard Jarvis. High Throughput In Vitro RNAi Screening: From Cell Lines To Primary Cells. Twelfth International Symposium on Recent Advances in Drug Delivery Systems (2005).
31. Dmitriy Ovcharenko. High throughput in vitro RNAi screening: From cell lines to primary cells. AACR 96th Annual Meeting, Cellular and Molecular Biology Symposium, Anaheim, CA (2005).
32. Dmitriy Ovcharenko, Richard Jarvis. High Throughput In Vitro RNAi Screening: From Cell Lines To Primary Cells. Twelfth International Symposium on Recent Advances in Drug Delivery Systems (2005).
33. Ovcharenko D. et al. Effective delivery of functional siRNAs into cells. Pharmaceutical Discovery, Current Applications in RNAi, p.21-26 (2005)
34. Ovcharenko D. et al. High throughput siRNA delivery in vitro: From cell lines to primary cells. Ambion TechNotes 12,(2): p.11-13 (2005)
35. Ovcharenko D. et al. High throughput siRNA electroporation. Ambion TechNotes 12,(1):p.14-15 (2005)
36. Ovcharenko D. et al. Deliver siRNAs into primary cells. Ambion TechNotes 12,(1):p.16-17 (2005)
37. Brown D. et al. Precursor miRNAs for successful miRNA functional studies. Ambion TechNotes 12,(1):p. 3-5 (2005)
38. Beauchamp L. et al. Got small RNA? Ambion TechNotes 12,(1):p.6-7 (2005)
39. Ovcharenko D. et al. Delivering siRNAs to difficult cell types. Ambion TechNotes 11,(3):p. 14-15 (2004)
40. Ovcharenko D. et al. Efficient delivery of siRNAs to human primary cells. Ambion TechNotes 10,(5):p.15-16 (2003)